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Gene : PROZ Homo sapiens

Name  ? protein Z, vitamin K dependent plasma glycoprotein Cytological Location  13q34
Brief Description  protein Z, vitamin K dependent plasma glycoprotein
Description  This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
  • synonyms:
  • uc001vta.3,
  • protein Z, vitamin K-dependent plasma glycoprotein,
  • OTTHUMG00000017376,
  • NM_003891,
  • PROZ,
  • HGNC:9460,
  • M55670,
  • PZ,
  • PZ
  • identifiers:
  • 8858,
  • ENSG00000126231,
  • PROZ

Genome feature

Region: gene ? Length: 16523  
Location: 13:113155864-113172386 Cyto location: 13q34


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

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SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

3756 SN Ps

5 Cross References

16 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results