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Gene : SPINK5 Homo sapiens

Name  ? serine peptidase inhibitor Kazal type 5 Cytological Location  5q32
Brief Description  serine peptidase inhibitor, Kazal type 5
description  This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
  • synonyms:
  • DKFZp686K19184,
  • NETS,
  • FLJ97536,
  • LEKTI,
  • LETKI,
  • VAKTI,
  • FLJ99794,
  • VAKTI,
  • OTTHUMG00000134305,
  • FLJ97596,
  • HGNC:15464,
  • NM_001127698,
  • LEKTI,
  • NS,
  • uc003lox.3,
  • serine protease inhibitor, Kazal type 5,
  • SPINK5,
  • NETS,
  • lymphoepithelial Kazal-type-related inhibitor,
  • FLJ21544,
  • LETKI,
  • NS,
  • AJ228139
  • identifiers:
  • 11005,
  • ENSG00000133710,
  • SPINK5

Genome feature

Region: gene ? Length: 73411  
Location: 5:148063972-148137382 Cyto location: 5q32

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3756 SN Ps

5 Cross References

18 Data Sets

17 Homologues

0 Located Features

97 Rna Seq Results