help  | about  | cite  | software

Gene : PRDM16 Homo sapiens

Name  ? PR/SET domain 16 Cytological Location  1p36.32
Brief Description  PR/SET domain 16
Description  The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PRDM16,
  • MGC166915,
  • uc001akf.4,
  • NM_022114,
  • MEL1,
  • transcription factor MEL1,
  • PR-domain zinc finger protein 16,
  • MDS1/EVI1-like,
  • AF294278,
  • MEL1,
  • CMD1LL,
  • KMT8F,
  • HGNC:14000,
  • OTTHUMG00000000581,
  • PR domain 16,
  • KMT8F,
  • PFM13,
  • PFM13,
  • LVNC8,
  • KIAA1675,
  • PR domain containing 16
  • identifiers:
  • 63976,
  • ENSG00000142611,
  • PRDM16

Genome feature

Region: gene ? Length: 369419  
Location: 1:3069203-3438621 Cyto location: 1p36.32

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



106 SN Ps

5 Cross References

18 Data Sets

18 Homologues

0 Located Features

97 Rna Seq Results