help  | about  | cite  | software

Gene : NECTIN4 Homo sapiens

Name  ? nectin cell adhesion molecule 4 Cytological Location  1q23.3
Brief Description  nectin cell adhesion molecule 4
Description  This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
  • synonyms:
  • poliovirus receptor-related 4,
  • PVRL4,
  • nectin-4,
  • LNIR,
  • AF426163,
  • LNIR,
  • HGNC:19688,
  • nectin-4,
  • PRR4,
  • PRR4,
  • OTTHUMG00000031475,
  • EDSS1,
  • NM_030916,
  • NECTIN4,
  • PVRL4,
  • uc001fxo.3
  • identifiers:
  • 81607,
  • ENSG00000143217,
  • NECTIN4

Genome feature

Region: gene ? Length: 18569  
Location: 1:161070998-161089566 reverse strand Cyto location: 1q23.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

20 SN Ps

5 Cross References

17 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results