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Gene : NECTIN4 Homo sapiens

Name  ? nectin cell adhesion molecule 4 Cytological Location  1q23.3
Brief Description  nectin cell adhesion molecule 4
Description  This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]
  • synonyms:
  • poliovirus receptor-related 4,
  • PVRL4,
  • nectin-4,
  • LNIR,
  • AF426163,
  • LNIR,
  • HGNC:19688,
  • nectin-4,
  • PRR4,
  • PRR4,
  • OTTHUMG00000031475,
  • EDSS1,
  • NM_030916,
  • NECTIN4,
  • PVRL4,
  • uc001fxo.3
  • identifiers:
  • 81607,
  • ENSG00000143217,

Genome feature

Region: gene ? Length: 18569  
Location: 1:161070998-161089566 reverse strand Cyto location: 1q23.3

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1 Diseases

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20 SN Ps

5 Cross References

17 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results