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Gene : PTPRJ Homo sapiens

Name  ? protein tyrosine phosphatase receptor type J Cytological Location  11p11.2
Brief Description  protein tyrosine phosphatase receptor type J
Description  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • R-PTP-ETA,
  • NM_001098503,
  • SCC1,
  • uc001ngp.5,
  • CD148,
  • CD148,
  • HGNC:9673,
  • DEP1,
  • DEP1,
  • U10886,
  • PTPRJ,
  • HPTPeta,
  • HPTPeta,
  • OTTHUMG00000166573
  • identifiers:
  • 5795,
  • ENSG00000149177,

Genome feature

Region: gene ? Length: 190336  
Location: 11:47980504-48170839 Cyto location: 11p11.2

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1 Diseases

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3756 SN Ps

5 Cross References

19 Data Sets

26 Homologues

0 Located Features

97 Rna Seq Results