help  | about  | cite  | software

Gene : GRM1 Homo sapiens

Name  ? glutamate metabotropic receptor 1 Cytological Location  6q24.3
Brief Description  glutamate metabotropic receptor 1
Description  This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • synonyms:
  • GRM1,
  • PPP1R85,
  • U31215,
  • OTTHUMG00000015752,
  • SCAR13,
  • MGLUR1,
  • GPRC1A,
  • uc032xoi.2,
  • HGNC:4593,
  • MGLU1,
  • protein phosphatase 1, regulatory subunit 85,
  • PPP1R85,
  • glutamate receptor, metabotropic 1,
  • SCA44,
  • GPRC1A,
  • NM_000838,
  • mGlu1,
  • MGLUR1
  • identifiers:
  • 2911,
  • ENSG00000152822,
  • GRM1

Genome feature

Region: gene ? Length: 409968  
Location: 6:146027634-146437601 Cyto location: 6q24.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

782 SN Ps

5 Cross References

20 Data Sets

13 Homologues

0 Located Features

97 Rna Seq Results