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Gene : PTPRK Homo sapiens

Name  ? protein tyrosine phosphatase receptor type K Cytological Location  6q22.33
Brief Description  protein tyrosine phosphatase receptor type K
Description  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_001135648,
  • HGNC:9674,
  • R-PTP-kappa,
  • uc003qbj.4,
  • OTTHUMG00000015536,
  • PTPRK,
  • R-PTP-kappa,
  • L77886
  • identifiers:
  • 5796,
  • ENSG00000152894,
  • PTPRK

Genome feature

Region: gene ? Length: 551819  
Location: 6:127968785-128520603 reverse strand Cyto location: 6q22.33


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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Other

538 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results