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Gene : MMP14 Homo sapiens

Name  ? matrix metallopeptidase 14 Cytological Location  14q11.2
Brief Description  matrix metallopeptidase 14
Description  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MT1-MMP,
  • membrane type 1 metalloprotease,
  • uc001whc.5,
  • MMP-X1,
  • MT1-MMP,
  • MT-MMP,
  • HGNC:7160,
  • MMP-14,
  • MT1MMP,
  • MTMMP1,
  • MT-MMP 1,
  • membrane type 1-matrix metalloproteinase,
  • matrix metallopeptidase 14 (membrane-inserted),
  • MMP14,
  • NM_004995,
  • OTTHUMG00000028704,
  • matrix metalloproteinase 14 (membrane-inserted)
  • identifiers:
  • 4323,
  • ENSG00000157227,
  • MMP14

Genome feature

Region: gene ? Length: 11174  
Location: 14:22836585-22847758 Cyto location: 14q11.2

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



56 SN Ps

5 Cross References

20 Data Sets

4 Homologues

2 Located Features

97 Rna Seq Results