help  | about  | cite  | software

Gene : NAE1 Homo sapiens

Name  ? NEDD8 activating enzyme E1 subunit 1 Cytological Location  16q22.1
Brief Description  NEDD8 activating enzyme E1 subunit 1
Description  The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • A-116A10.1,
  • NM_003905,
  • ula-1,
  • APP-BP1,
  • ula-1,
  • OTTHUMG00000137513,
  • NAE1,
  • APPBP1,
  • uc002eqf.4,
  • U50939,
  • APPBP1,
  • amyloid beta precursor protein binding protein 1, 59kDa,
  • HGNC:621,
  • HPP1
  • identifiers:
  • 8883,
  • ENSG00000159593,
  • NAE1

Genome feature

Region: gene ? Length: 28100  
Location: 16:66802878-66830977 reverse strand Cyto location: 16q22.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3756 SN Ps

5 Cross References

16 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results