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Gene : LRWD1 Homo sapiens

Name  ? leucine rich repeats and WD repeat domain containing 1 Cytological Location  7q22.1
Brief Description  leucine rich repeats and WD repeat domain containing 1
Description  The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
  • synonyms:
  • CENP-33,
  • HGNC:21769,
  • uc003uzn.4,
  • ORCA,
  • NM_152892,
  • AL133057,
  • DKFZp434K1815,
  • centromere protein 33,
  • CENP-33,
  • LRWD1,
  • origin recognition complex associated,
  • ORCA,
  • OTTHUMG00000157718
  • identifiers:
  • 222229,
  • ENSG00000161036,
  • LRWD1

Genome feature

Region: gene ? Length: 8286  
Location: 7:102464883-102473168 Cyto location: 7q22.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

3756 SN Ps

5 Cross References

14 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results