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Gene : PTPN13 Homo sapiens

Name  ? protein tyrosine phosphatase non-receptor type 13 Cytological Location  4q21.3
Brief Description  protein tyrosine phosphatase non-receptor type 13
Description  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
  • synonyms:
  • PTP1E,
  • OTTHUMG00000160968,
  • uc003hpz.4,
  • hPTP1E,
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase),
  • APO-1/CD95 (Fas)-associated phosphatase,
  • NM_006264,
  • FAP-1,
  • PTP1E,
  • PTPN13,
  • HGNC:9646,
  • PNP1,
  • PTPL1,
  • PTP-BAS,
  • PTPLE,
  • PTP-BL,
  • PTP-BL,
  • PTPL1,
  • identifiers:
  • 5783,
  • ENSG00000163629,
  • PTPN13

Genome feature

Region: gene ? Length: 220870  
Location: 4:86594307-86815176 Cyto location: 4q21.3

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3753 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results