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Gene : MCM7 Homo sapiens

Name  ? minichromosome maintenance complex component 7 Cytological Location  7q22.1
Brief Description  minichromosome maintenance complex component 7
description  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • synonyms:
  • PNAS146,
  • OTTHUMG00000154671,
  • uc003usw.3,
  • MCM7,
  • protein phosphatase 1, regulatory subunit 104,
  • P1.1-MCM3,
  • P1CDC47,
  • PPP1R104,
  • P85MCM,
  • MCM2,
  • MCM7 minichromosome maintenance deficient 7 (S. cerevisiae),
  • CDC47,
  • PPP1R104,
  • minichromosome maintenance deficient (S. cerevisiae) 7,
  • HGNC:6950,
  • NM_001278595,
  • MCM2,
  • CDC47
  • identifiers:
  • 4176,
  • ENSG00000166508,
  • MCM7

Genome feature

Region: gene ? Length: 8670  
Location: 7:100092728-100101397 reverse strand Cyto location: 7q22.1

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3756 SN Ps

5 Cross References

16 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results