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Gene : RAB8A Homo sapiens

Name  ? RAB8A, member RAS oncogene family Cytological Location  19p13.11
Brief Description  RAB8A, member RAS oncogene family
Description  The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_005370,
  • MEL,
  • OTTHUMG00000182238,
  • RAB8,
  • mel transforming oncogene (derived from cell line NK14),
  • RAB8A,
  • uc002ndn.5,
  • HGNC:7007,
  • RAB8,
  • MEL
  • identifiers:
  • 4218,
  • ENSG00000167461,
  • RAB8A

Genome feature

Region: gene ? Length: 22346  
Location: 19:16111889-16134234 Cyto location: 19p13.11


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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

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Expression

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868 SN Ps

5 Cross References

15 Data Sets

75 Homologues

1 Located Features

97 Rna Seq Results