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Gene : HOXD4 Homo sapiens

Name  ? homeobox D4 Cytological Location  2q31.1
Brief Description  homeobox D4
Description  This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002uks.4,
  • Hox-4.2,
  • HOX-5.1,
  • HOX4,
  • HOX4,
  • OTTHUMG00000132515,
  • HOXD4,
  • NM_014621,
  • homeo box D4,
  • HGNC:5138,
  • HHO.C13,
  • HOX4B,
  • HOX4B
  • identifiers:
  • 3233,
  • ENSG00000170166,
  • HOXD4

Genome feature

Region: gene ? Length: 5685  
Location: 2:176150394-176156078 Cyto location: 2q31.1


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

243 SN Ps

5 Cross References

15 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results