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Gene : STAT2 Homo sapiens

Name  ? signal transducer and activator of transcription 2 Cytological Location  12q13.3
Brief Description  signal transducer and activator of transcription 2
Description  The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
  • synonyms:
  • BC051284,
  • uc001slc.4,
  • signal transducer and activator of transcription 2, 113kD,
  • STAT2,
  • P113,
  • signal transducer and activator of transcription 2, 113kDa,
  • OTTHUMG00000170760,
  • NM_005419,
  • STAT113,
  • HGNC:11363,
  • STAT113,
  • ISGF-3,
  • IMD44
  • identifiers:
  • 6773,
  • ENSG00000170581,
  • STAT2

Genome feature

Region: gene ? Length: 18565  
Location: 12:56341597-56360161 reverse strand Cyto location: 12q13.3


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1 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results