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Gene : PPM1D Homo sapiens

Name  ? protein phosphatase, Mg2+/Mn2+ dependent 1D Cytological Location  17q23.2
Brief Description  protein phosphatase, Mg2 /Mn2 dependent 1D
Description  The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
  • synonyms:
  • JDVS,
  • PPM1D,
  • protein phosphatase 2C, delta isoform,
  • U78305,
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D,
  • Wip1,
  • WIP1,
  • HGNC:9277,
  • OTTHUMG00000180052,
  • NM_003620,
  • uc002iyt.3,
  • wild-type p53-induced phosphatase 1,
  • protein phosphatase 1D magnesium-dependent, delta isoform
  • identifiers:
  • 8493,
  • ENSG00000170836,
  • PPM1D

Genome feature

Region: gene ? Length: 66094  
Location: 17:60600187-60666280 Cyto location: 17q23.2

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2 Diseases

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59 SN Ps

5 Cross References

20 Data Sets

22 Homologues

0 Located Features

97 Rna Seq Results