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Gene : PACS1 Homo sapiens

Name  ? phosphofurin acidic cluster sorting protein 1 Cytological Location  11q13.1-q13.2
Brief Description  phosphofurin acidic cluster sorting protein 1
Description  This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MRD17,
  • PACS1,
  • AB033001,
  • HGNC:30032,
  • FLJ10209,
  • uc001oha.3,
  • KIAA1175,
  • SHMS,
  • NM_018026,
  • OTTHUMG00000166889
  • identifiers:
  • 55690,
  • ENSG00000175115,
  • PACS1

Genome feature

Region: gene ? Length: 174473  
Location: 11:66070272-66244744 Cyto location: 11q13.1-q13.2


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

3756 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results