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Gene : SART1 Homo sapiens

Name  ? spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Cytological Location  11q13.1
Brief Description  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
description  This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HAF,
  • SNRNP110,
  • squamous cell carcinoma antigen recognized by T cells 1,
  • small nuclear ribonucleoprotein 110kDa (U4/U6.U5),
  • OTTHUMG00000166771,
  • SNRNP110,
  • Snu66,
  • NM_005146,
  • SART1259,
  • Ara1,
  • Ara1,
  • Snu66,
  • squamous cell carcinoma antigen recognized by T-cells 1,
  • HGNC:10538,
  • SART1,
  • HOMS1,
  • uc001ogl.4,
  • AB006198,
  • hypoxia associated factor,
  • squamous cell carcinoma antigen recognised by T cells,
  • HAF,
  • SART1, U4/U6.U5 tri-snRNP-associated protein 1
  • identifiers:
  • 9092,
  • ENSG00000175467,
  • SART1

Genome feature

Region: gene ? Length: 18411  
Location: 11:65961727-65980137 Cyto location: 11q13.1

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0 Diseases

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136 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results