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Gene : GPX2 Homo sapiens

Name  ? glutathione peroxidase 2 Cytological Location  14q23.3
Brief Description  glutathione peroxidase 2
Description  The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
  • synonyms:
  • OTTHUMG00000171677,
  • glutathione peroxidase 2 (gastrointestinal),
  • GPRP,
  • GPX2,
  • GPx-GI,
  • NM_002083,
  • uc021ruq.3,
  • GI-GPx,
  • GPx-2,
  • GPRP-2,
  • GSHPx-2,
  • HGNC:4554
  • identifiers:
  • 2877,
  • ENSG00000176153,
  • GPX2

Genome feature

Region: gene ? Length: 3588  
Location: 14:64939158-64942745 reverse strand Cyto location: 14q23.3

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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3756 SN Ps

5 Cross References

16 Data Sets

13 Homologues

0 Located Features

97 Rna Seq Results