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Gene : TYMS Homo sapiens

Name  ? thymidylate synthetase Cytological Location  18p11.32
Brief Description  thymidylate synthetase
Description  Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
  • synonyms:
  • OTTHUMG00000131473,
  • TMS,
  • HST422,
  • Tsase,
  • TS,
  • HsT422,
  • NM_001071,
  • HGNC:12441,
  • uc010dka.2,
  • TMS,
  • TS,
  • TYMS,
  • X02308
  • identifiers:
  • 7298,
  • ENSG00000176890,
  • TYMS

Genome feature

Region: gene ? Length: 15926  
Location: 18:657653-673578 Cyto location: 18p11.32


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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Expression

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Other

908 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results