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Gene : IDH2 Homo sapiens

Name  ? isocitrate dehydrogenase (NADP(+)) 2 Cytological Location  15q26.1
Brief Description  isocitrate dehydrogenase (NADP( )) 2
Description  Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
  • synonyms:
  • uc002box.4,
  • ICD-M,
  • HGNC:5383,
  • NM_001289910,
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial,
  • D2HGA2,
  • IDP,
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial,
  • OTTHUMG00000149815,
  • mNADP-IDH,
  • IDH2,
  • IDPM,
  • IDH,
  • IDHM
  • identifiers:
  • 3418,
  • ENSG00000182054,
  • IDH2

Genome feature

Region: gene ? Length: 19424  
Location: 15:90083045-90102468 reverse strand Cyto location: 15q26.1

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1 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results