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Gene : KPNA2 Homo sapiens

Name  ? karyopherin subunit alpha 2 Cytological Location  17q24.2
Brief Description  karyopherin subunit alpha 2
description  The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  • synonyms:
  • NM_002266,
  • RCH1,
  • SRP1-alpha,
  • HGNC:6395,
  • QIP2,
  • OTTHUMG00000179784,
  • KPNA2,
  • IPOA1,
  • RAG cohort 1,
  • U09559,
  • karyopherin alpha 2,
  • QIP2,
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1),
  • uc002jgk.4,
  • IPOA1,
  • importin alpha 1,
  • SRP1alpha,
  • SRP1alpha,
  • RCH1
  • identifiers:
  • 3838,
  • ENSG00000182481,
  • KPNA2

Genome feature

Region: gene ? Length: 11125  
Location: 17:68035735-68046859 Cyto location: 17q24.2

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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808 SN Ps

5 Cross References

15 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results