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Gene : WWOX Homo sapiens

Name  ? WW domain containing oxidoreductase Cytological Location  16q23.1-q23.2
Brief Description  WW domain containing oxidoreductase
description  This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
  • synonyms:
  • EIEE28,
  • PRO0128,
  • WW domain-containing oxidoreductase,
  • WOX1,
  • WOX1,
  • HHCMA56,
  • SCAR12,
  • WWOX,
  • FOR,
  • D16S432E,
  • OTTHUMG00000176851,
  • NM_001291997,
  • FOR,
  • FRA16D,
  • uc002ffk.4,
  • SDR41C1,
  • SDR41C1,
  • AF187015,
  • HGNC:12799,
  • short chain dehydrogenase/reductase family 41C, member 1
  • identifiers:
  • 51741,
  • ENSG00000186153,
  • WWOX

Genome feature

Region: gene ? Length: 1113014  
Location: 16:78099654-79212667 Cyto location: 16q23.1-q23.2

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3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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3756 SN Ps

5 Cross References

19 Data Sets

19 Homologues

0 Located Features

97 Rna Seq Results