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Gene : LRRK2 Homo sapiens

Name  ? leucine rich repeat kinase 2 Cytological Location  12q12
Brief Description  leucine rich repeat kinase 2
Description  This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
  • synonyms:
  • ROCO2,
  • uc001rmg.5,
  • OTTHUMG00000059742,
  • dardarin,
  • DARDARIN,
  • Parkinson disease (autosomal dominant) 8,
  • FLJ45829,
  • AK026776,
  • NM_198578,
  • AURA17,
  • RIPK7,
  • PARK8,
  • LRRK2,
  • PARK8,
  • HGNC:18618,
  • ROCO2,
  • DKFZp434H2111,
  • RIPK7
  • identifiers:
  • 120892,
  • ENSG00000188906,
  • LRRK2

Genome feature

Region: gene ? Length: 144396  
Location: 12:40224890-40369285 Cyto location: 12q12


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

3756 SN Ps

5 Cross References

19 Data Sets

31 Homologues

0 Located Features

97 Rna Seq Results