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Gene : LITAF Homo sapiens

Name  ? lipopolysaccharide induced TNF factor Cytological Location  16p13.13
Brief Description  lipopolysaccharide induced TNF factor
Description  Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
  • synonyms:
  • FLJ38636,
  • LITAF,
  • SIMPLE,
  • OTTHUMG00000177415,
  • TP53I7,
  • TP53I7,
  • lipopolysaccharide-induced TNF factor,
  • AB034747,
  • PIG7,
  • SIMPLE,
  • HGNC:16841,
  • uc059qvo.1,
  • NM_004862,
  • PIG7
  • identifiers:
  • 9516,
  • ENSG00000189067,
  • LITAF

Genome feature

Region: gene ? Length: 88656  
Location: 16:11547722-11636377 reverse strand Cyto location: 16p13.13


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0 Pathways

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Gene -> HPO annotation (Human Phenotype Ontology)

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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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0 Pathways

3756 SN Ps

5 Cross References

19 Data Sets

31 Homologues

0 Located Features

97 Rna Seq Results