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Gene : TXNRD1 Homo sapiens

Name  ? thioredoxin reductase 1 Cytological Location  12q23.3
Brief Description  thioredoxin reductase 1
Description  The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
  • synonyms:
  • HGNC:12437,
  • TXNR,
  • TXNRD1,
  • TR1,
  • Trxr1,
  • TXNR,
  • GRIM-12,
  • OTTHUMG00000166481,
  • NM_003330,
  • TR,
  • GRIM-12,
  • TRXR1,
  • uc021rcx.3
  • identifiers:
  • 7296,
  • ENSG00000198431,
  • TXNRD1

Genome feature

Region: gene ? Length: 134529  
Location: 12:104215779-104350307 Cyto location: 12q23.3

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154 SN Ps

5 Cross References

17 Data Sets

5 Homologues

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97 Rna Seq Results