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Gene : LAT Homo sapiens

Name  ? linker for activation of T cells Cytological Location  16p11.2
Brief Description  linker for activation of T cells
description  The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • IMD52,
  • LAT,
  • OTTHUMG00000131761,
  • LAT1,
  • linker for activation of T cells, transmembrane adaptor,
  • AF036905,
  • pp36,
  • HGNC:18874,
  • NM_001014987,
  • uc002dsd.4,
  • LAT1
  • identifiers:
  • 27040,
  • ENSG00000213658,
  • LAT

Genome feature

Region: gene ? Length: 5982  
Location: 16:28984803-28990784 Cyto location: 16p11.2

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1 Diseases

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3756 SN Ps

5 Cross References

19 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results