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Gene : HLA-DMB Homo sapiens

Name  ? major histocompatibility complex, class II, DM beta Cytological Location  6p21.32
Brief Description  major histocompatibility complex, class II, DM beta
Description  HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
  • synonyms:
  • D6S221E,
  • HGNC:4935,
  • NM_002118,
  • OTTHUMG00000031176,
  • uc063vxr.1,
  • RING7,
  • D6S221E,
  • HLA-DMB,
  • RING7
  • identifiers:
  • 3109,
  • ENSG00000242574,
  • HLA-DMB

Genome feature

Region: gene ? Length: 6393  
Location: 6:32934636-32941028 reverse strand Cyto location: 6p21.32


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3753 SN Ps

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results