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Gene : BCL2L10 Homo sapiens

Name  ? BCL2 like 10 Cytological Location  15q21.2
Brief Description  BCL2 like 10
Description  The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
  • synonyms:
  • bcl2-L-10,
  • AF285092,
  • BCL-B,
  • HGNC:993,
  • NM_001306168,
  • Diva,
  • Boo,
  • OTTHUMG00000131893,
  • uc002abq.4,
  • BCL2L10,
  • BCL-B,
  • BCL2-like 10 (apoptosis facilitator),
  • Diva,
  • Boo
  • identifiers:
  • 10017,
  • ENSG00000137875,
  • BCL2L10

Genome feature

Region: gene ? Length: 3513  
Location: 15:52109263-52112775 reverse strand Cyto location: 15q21.2


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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

421 SN Ps

5 Cross References

15 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results