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Gene : BCL2L11 Homo sapiens

Name  ? BCL2 like 11 Cytological Location  2q13
Brief Description  BCL2 like 11
Description  The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
  • synonyms:
  • BOD,
  • BCL2-like 11 (apoptosis facilitator),
  • BCL2L11,
  • BimL,
  • BAM,
  • AF032458,
  • BIM,
  • uc002tgv.2,
  • BimS,
  • BimEL,
  • NM_001204106,
  • BOD,
  • OTTHUMG00000131256,
  • BIM,
  • HGNC:994
  • identifiers:
  • 10018,
  • ENSG00000153094,
  • BCL2L11

Genome feature

Region: gene ? Length: 47532  
Location: 2:111120914-111168445 Cyto location: 2q13


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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

527 SN Ps

5 Cross References

15 Data Sets

6 Homologues

1 Located Features

97 Rna Seq Results