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Gene : CDH4 Homo sapiens

Name  ? cadherin 4 Cytological Location  20q13.33
Brief Description  cadherin 4
Description  This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • synonyms:
  • HGNC:1763,
  • uc032pok.1,
  • OTTHUMG00000032890,
  • R-Cadherin,
  • R-CAD,
  • NM_001794,
  • CAD4,
  • RCAD,
  • CDH4,
  • cadherin 4, type 1, R-cadherin (retinal),
  • L34059
  • identifiers:
  • 1002,
  • ENSG00000179242,
  • CDH4

Genome feature

Region: gene ? Length: 688357  
Location: 20:61252261-61940617 Cyto location: 20q13.33


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

3753 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results