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Gene : ABCC5 Homo sapiens

Name  ? ATP binding cassette subfamily C member 5 Cytological Location  3q27.1
Brief Description  ATP binding cassette subfamily C member 5
Description  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  • synonyms:
  • MRP5,
  • SMRP,
  • ABCC5,
  • MOAT-C,
  • MOAT-C,
  • MOATC,
  • EST277145,
  • AF104942,
  • HGNC:56,
  • MRP5,
  • OTTHUMG00000156871,
  • NM_005688,
  • pABC11,
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 5,
  • EST277145,
  • SMRP,
  • uc003fmg.4,
  • ABC33
  • identifiers:
  • 10057,
  • ENSG00000114770,
  • ABCC5

Genome feature

Region: gene ? Length: 98077  
Location: 3:183919934-184018010 reverse strand Cyto location: 3q27.1


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Disease

0 Diseases

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3756 SN Ps

5 Cross References

18 Data Sets

23 Homologues

0 Located Features

97 Rna Seq Results