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Gene : CDH12 Homo sapiens

Name  ? cadherin 12 Cytological Location  5p14.3
Brief Description  cadherin 12
Description  This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]
  • synonyms:
  • L33477,
  • HGNC:1751,
  • cadherin 12, type 2 (N-cadherin 2),
  • Br-cadherin,
  • CDHB,
  • OTTHUMG00000090591,
  • CDHB,
  • CDH12,
  • NM_004061,
  • uc063cos.1
  • identifiers:
  • 1010,
  • ENSG00000154162,
  • CDH12

Genome feature

Region: gene ? Length: 1102672  
Location: 5:21750673-22853344 reverse strand Cyto location: 5p14.3

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0 Diseases

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3740 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results