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Gene : CDK4 Homo sapiens

Name  ? cyclin dependent kinase 4 Cytological Location  12q14.1
Brief Description  cyclin dependent kinase 4
Description  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CMM3,
  • CDK4,
  • NM_000075,
  • uc001spv.4,
  • PSK-J3,
  • M14505,
  • PSK-J3,
  • OTTHUMG00000170382,
  • HGNC:1773
  • identifiers:
  • 1019,
  • ENSG00000135446,
  • CDK4

Genome feature

Region: gene ? Length: 4584  
Location: 12:57747727-57752310 reverse strand Cyto location: 12q14.1


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Function

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47 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

47 Pathways

115 SN Ps

5 Cross References

18 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results