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Gene : CDKN1B Homo sapiens

Name  ? cyclin dependent kinase inhibitor 1B Cytological Location  12p13.1
Brief Description  cyclin dependent kinase inhibitor 1B
Description  This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
  • synonyms:
  • OTTHUMG00000149914,
  • P27KIP1,
  • KIP1,
  • KIP1,
  • NM_004064,
  • CDKN4,
  • HGNC:1785,
  • CDKN1B,
  • AF480891,
  • MEN4,
  • MEN1B,
  • P27KIP1,
  • uc001rat.3,
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • identifiers:
  • 1027,
  • ENSG00000111276,
  • CDKN1B

Genome feature

Region: gene ? Length: 5002  
Location: 12:12717368-12722369 Cyto location: 12p13.1

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49 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



49 Pathways

22 SNPs

5 Cross References

19 Data Sets

7 Homologues

1 Located Features

97 Rna Seq Results