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Gene : CDKN2B Homo sapiens

Name  ? cyclin dependent kinase inhibitor 2B Cytological Location  9p21.3
Brief Description  cyclin dependent kinase inhibitor 2B
Description  This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CDK4I,
  • MTS2,
  • P15,
  • P15,
  • INK4B,
  • MTS2,
  • TP15,
  • TP15,
  • CDK4I,
  • NM_004936,
  • CDKN2B,
  • HGNC:1788,
  • p15INK4b,
  • INK4B,
  • p15INK4b,
  • uc003zpo.4,
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4),
  • AB060808,
  • OTTHUMG00000019691
  • identifiers:
  • 1030,
  • ENSG00000147883,
  • CDKN2B

Genome feature

Region: gene ? Length: 6411  
Location: 9:22002903-22009313 reverse strand Cyto location: 9p21.3

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0 Diseases

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265 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results