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Gene : IKZF1 Homo sapiens

Name  ? IKAROS family zinc finger 1 Cytological Location  7p12.2
Brief Description  IKAROS family zinc finger 1
Description  This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
  • synonyms:
  • PRO0758,
  • OTTHUMG00000155907,
  • PPP1R92,
  • LyF-1,
  • IKAROS,
  • NM_006060,
  • ZNFN1A1,
  • IKAROS,
  • PPP1R92,
  • Hs.54452,
  • IKAROS family zinc finger 1 (Ikaros),
  • Hs.54452,
  • hIk-1,
  • IK1,
  • zinc finger protein, subfamily 1A, 1 (Ikaros),
  • ZNFN1A1,
  • protein phosphatase 1, regulatory subunit 92,
  • LyF-1,
  • uc003tow.5,
  • CVID13,
  • HGNC:13176,
  • LYF1,
  • IKZF1,
  • U40462
  • identifiers:
  • 10320,
  • ENSG00000185811,
  • IKZF1

Genome feature

Region: gene ? Length: 101649  
Location: 7:50303453-50405101 Cyto location: 7p12.2


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Disease

1 Diseases

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0 Pathways

62 SN Ps

5 Cross References

19 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results