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Gene : CLEC4M Homo sapiens

Name  ? C-type lectin domain family 4 member M Cytological Location  19p13.2
Brief Description  C-type lectin domain family 4 member M
Description  This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]
  • synonyms:
  • DC-SIGN2,
  • LSIGN,
  • L-SIGN,
  • HP10347,
  • DC-SIGN2,
  • CD299,
  • HP10347,
  • CD299 antigen,
  • OTTHUMG00000182432,
  • NM_014257,
  • uc010dvt.3,
  • CD209L,
  • CD299,
  • AB015629,
  • C-type lectin domain family 4, member M,
  • CLEC4M,
  • HGNC:13523,
  • CD209L,
  • LSIGN,
  • identifiers:
  • 10332,
  • ENSG00000104938,
  • CLEC4M

Genome feature

Region: gene ? Length: 6363  
Location: 19:7763243-7769605 Cyto location: 19p13.2

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

433 SNPs

5 Cross References

16 Data Sets

22 Homologues

0 Located Features

97 Rna Seq Results