help  | about  | cite  | software

Gene : GPNMB Homo sapiens

Name  ? glycoprotein nmb Cytological Location  7p15.3
Brief Description  glycoprotein nmb
Description  The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:4462,
  • glycoprotein nmb-like protein,
  • NM_001005340,
  • transmembrane glycoprotein,
  • HGFIN,
  • NMB,
  • NMB,
  • HGFIN,
  • glycoprotein NMB,
  • hematopoietic growth factor inducible neurokinin-1,
  • uc003swb.4,
  • OTTHUMG00000022811,
  • GPNMB,
  • glycoprotein (transmembrane) nmb,
  • PLCA3,
  • X76534,
  • glycoprotein nonmetastatic melanoma protein B,
  • osteoactivin
  • identifiers:
  • 10457,
  • ENSG00000136235,

Genome feature

Region: gene ? Length: 28345  
Location: 7:23246766-23275110 Cyto location: 7p15.3

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

18 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results