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Gene : DCTN2 Homo sapiens

Name  ? dynactin subunit 2 Cytological Location  12q13.3
Brief Description  dynactin subunit 2
Description  This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
  • synonyms:
  • DCTN-50,
  • U50733,
  • OTTHUMG00000170124,
  • DCTN50,
  • uc001som.3,
  • HEL-S-77,
  • dynactin 2 (p50),
  • RBP50,
  • DCTN2,
  • DYNAMITIN,
  • HGNC:2712,
  • RBP50,
  • NM_006400
  • identifiers:
  • 10540,
  • ENSG00000175203,
  • DCTN2

Genome feature

Region: gene ? Length: 17282  
Location: 12:57530050-57547331 reverse strand Cyto location: 12q13.3


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255 SN Ps

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17 Data Sets

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97 Rna Seq Results