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Gene : AGR2 Homo sapiens

Name  ? anterior gradient 2, protein disulphide isomerase family member Cytological Location  7p21.1
Brief Description  anterior gradient 2, protein disulphide isomerase family member
Description  This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
  • synonyms:
  • AG2,
  • HAG-2,
  • AGR2,
  • HEL-S-116,
  • HAG-2,
  • AF038451,
  • XAG-2,
  • PDIA17,
  • NM_006408,
  • uc003str.4,
  • GOB-4,
  • anterior gradient 2 homolog (Xenopus laevis),
  • OTTHUMG00000023446,
  • HPC8,
  • XAG-2,
  • AG2,
  • AG-2,
  • HGNC:328,
  • PDIA17,
  • protein disulfide isomerase family A, member 17
  • identifiers:
  • 10551,
  • ENSG00000106541,
  • AGR2

Genome feature

Region: gene ? Length: 13189  
Location: 7:16791811-16804999 reverse strand Cyto location: 7p21.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Pathways

3740 SNPs

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results