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Gene : CENPB Homo sapiens

Name  ? centromere protein B Cytological Location  20p13
Brief Description  centromere protein B
Description  This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000031761,
  • uc002wjk.3,
  • CENPB,
  • centromere protein B (80kD),
  • centromere protein B, 80kDa,
  • HGNC:1852,
  • X05299,
  • NM_001810
  • identifiers:
  • 1059,
  • ENSG00000125817,
  • CENPB

Genome feature

Region: gene ? Length: 2890  
Location: 20:3783851-3786740 reverse strand Cyto location: 20p13


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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

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SNPs

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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

189 SN Ps

5 Cross References

15 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results