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Gene : CXCR6 Homo sapiens

Name  ? C-X-C motif chemokine receptor 6 Cytological Location  3p21.31
Brief Description  C-X-C motif chemokine receptor 6
Description  The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]
  • synonyms:
  • HGNC:16647,
  • uc062izf.1,
  • CD186,
  • CD186,
  • CDw186,
  • BONZO,
  • CXCR6,
  • chemokine (C-X-C motif) receptor 6,
  • STRL33,
  • NM_001386435,
  • AF007545,
  • OTTHUMG00000133448,
  • STRL33,
  • identifiers:
  • 10663,
  • ENSG00000172215,
  • CXCR6

Genome feature

Region: gene ? Length: 7437  
Location: 3:45940915-45948351 Cyto location: 3p21.31

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SNPs

4 Cross References

13 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results