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Gene : CFL1 Homo sapiens

Name  ? cofilin 1 Cytological Location  11q13.1
Brief Description  cofilin 1
Description  The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
  • synonyms:
  • CFL,
  • cofilin 1 (non-muscle),
  • CFL1,
  • cofilin,
  • OTTHUMG00000166602,
  • X95404,
  • uc001oft.4,
  • NM_005507,
  • HGNC:1874,
  • CFL,
  • HEL-S-15
  • identifiers:
  • 1072,
  • ENSG00000172757,
  • CFL1

Genome feature

Region: gene ? Length: 3508  
Location: 11:65854673-65858180 reverse strand Cyto location: 11q13.1


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Disease

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967 SN Ps

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17 Data Sets

10 Homologues

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97 Rna Seq Results