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Gene : CPSF4 Homo sapiens

Name  ? cleavage and polyadenylation specific factor 4 Cytological Location  7q22.1
Brief Description  cleavage and polyadenylation specific factor 4
Description  Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc003uqj.4,
  • cleavage and polyadenylation specific factor 4, 30kDa,
  • cleavage and polyadenylation specific factor 4, 30kD subunit,
  • CPSF30,
  • NEB1,
  • NAR,
  • HGNC:2327,
  • NEB-1,
  • NM_001081559,
  • OTTHUMG00000154599,
  • NAR,
  • CPSF30,
  • CPSF4
  • identifiers:
  • 10898,
  • ENSG00000160917,
  • CPSF4

Genome feature

Region: gene ? Length: 18466  
Location: 7:99438912-99457377 Cyto location: 7q22.1


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927 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results