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Gene : COPS8 Homo sapiens

Name  ? COP9 signalosome subunit 8 Cytological Location  2q37.3
Brief Description  COP9 signalosome subunit 8
Description  The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • synonyms:
  • OTTHUMG00000133297,
  • uc002vwh.4,
  • MGC1297,
  • SGN8,
  • COP9,
  • CSN8,
  • COP9,
  • CSN8,
  • NM_006710,
  • SGN8,
  • COPS8,
  • COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis),
  • HGNC:24335
  • identifiers:
  • 10920,
  • ENSG00000198612,
  • COPS8

Genome feature

Region: gene ? Length: 14586  
Location: 2:237085889-237100474 Cyto location: 2q37.3

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Gene -> HPO annotation (Human Phenotype Ontology)

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Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



814 SNPs

5 Cross References

15 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results