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Gene : COPS5 Homo sapiens

Name  ? COP9 signalosome subunit 5 Cytological Location  8q13.1
Brief Description  COP9 signalosome subunit 5
Description  The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
  • synonyms:
  • COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis),
  • NM_006837,
  • JAB1,
  • SGN5,
  • COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5,
  • MOV-34,
  • CSN5,
  • U65928,
  • MOV-34,
  • HGNC:2240,
  • SGN5,
  • OTTHUMG00000164563,
  • CSN5,
  • COPS5,
  • JAB1,
  • uc003xxe.4
  • identifiers:
  • 10987,
  • ENSG00000121022,
  • COPS5

Genome feature

Region: gene ? Length: 19055  
Location: 8:67043079-67062133 reverse strand Cyto location: 8q13.1

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Ontology

Gene --> GO terms.



386 SN Ps

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results