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Gene : CNMD Homo sapiens

Name  ? chondromodulin Cytological Location  13q14.3
Brief Description  chondromodulin
Description  This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • synonyms:
  • BRICD3,
  • HGNC:17005,
  • CNMD,
  • multiple myeloma tumor suppressor 1,
  • BRICD3,
  • MYETS1,
  • uc001vhf.4,
  • CHM1,
  • NM_001011705,
  • CHM1,
  • AB006000,
  • BRICHOS domain containing 3,
  • MYETS1,
  • CHM-I,
  • CHM-I,
  • OTTHUMG00000016980,
  • LECT1,
  • leukocyte cell derived chemotaxin 1,
  • LECT1
  • identifiers:
  • 11061,
  • ENSG00000136110,
  • CNMD

Genome feature

Region: gene ? Length: 36557  
Location: 13:52703264-52739820 reverse strand Cyto location: 13q14.3


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0 Pathways

213 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results