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Gene : 111365160 Homo sapiens

Description  This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. Two sub-regions were validated as functional enhancers by high-throughput massively parallel reporter assays (MPRAs) in both HepG2 liver carcinoma cells and K562 erythroleukemia cells. Each sub-region contains two motifs for the NFE2L2 activator. Mutation of either motif results in reduced enhancer activity. This region was also validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with MPRAs) in both HepG2 cells (group: HepG2 Activating DNase matched - State 5:Enh, candidate strong enhancer, open chromatin) and K562 cells (group: K562 Activating DNase unmatched - State 1:Tss, active promoter, TSS/CpG island region). [provided by RefSeq, Nov 2018]
  • identifiers:
  • 111365160

Genome feature

Region: gene ?
Location: No location information in HumanMine

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Mouse Gene --> Allele [Phenotype]


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