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Gene : FBXO32 Homo sapiens

Name  ? F-box protein 32 Cytological Location  8q24.13
Brief Description  F-box protein 32
Description  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
  • synonyms:
  • MAFbx,
  • HGNC:16731,
  • F-box only protein 32,
  • NM_001242463,
  • Fbx32,
  • ATROGIN1,
  • uc003yqr.4,
  • OTTHUMG00000164981,
  • AJ420108,
  • MAFbx,
  • Fbx32,
  • FBXO32
  • identifiers:
  • 114907,
  • ENSG00000156804,
  • FBXO32

Genome feature

Region: gene ? Length: 43320  
Location: 8:123497887-123541206 reverse strand Cyto location: 8q24.13


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220 SN Ps

5 Cross References

15 Data Sets

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97 Rna Seq Results